To Rome

After an overnight flight to Rome, you may not be able to get into your room upon arrival. My advice is to get some sleep on the plane. On your way to Rome take some over the counter sleep meds or other stuff so that you get at least 2-4 hours of sleep. Flight time from the east coast direct to Rome is about 8 hours (return flight is over 9 hours); but, who cares if your're tired at home. Suzanne and I leave Boston at 1050 pm on Sunday and arrive in Rome airport at 1250 pm on Monday; a 14 hour clock change. By the time we arrive to the Una Hotel in Rome it will be after 3pm. We will probably get into our room without trouble at that time.
After a travel day that begins on Monday around 9 am in Webster, Florida, the rest of our party leaves JFK in NY at 420 pm and arrive in Italy at 645 am on the 15th. They may not get into their rooms right away. By the time they get to the hotel they may have traveled for 24 hours. They will be able to use our room if needed.

Leonardo da Vinci International Airport, usually called Fiumicino Airport (few-me-chee-no), is 18 miles west of the city. It takes 45 to 60 minutes to drive to Rome.

PS: Leaving Italy's Fiumicino Airport takes a while. All flights out of Rome to the U.S. leave from the separate Terminal 5 ("T5"), which is located, roughly, in Timbuktu.
Terminal 5—a former cargo terminal that is used exclusively for flights to the U.S. and Israel—is a 15 minute ride away from everything else on a shuttle that passes by only every 20–30 minutes or so. (And yes, it's pretty much impossible to walk to it, since most of the journey is on a sidewalk-less elevated ramp.) This is not Italy's fault. It has to do with the asinine extra security protocols of the TSA (and of Israel).